Low Grade Glioma

By OncoLearnersForum

When to give Radiation in LGG?

1- J Clin Oncol. 2002 (P-III TRIAL)

Prognostic Factors for Survival in Adult Patients WithCerebral Low-Grade Glioma

Can we delay RT in LGG?

2- Lancet. 2005 (EORTC 22845 RCT)

Long-term efficacy of early versus delayed radiotherapy for low-grade astrocytoma and oligodendroglioma in adults: the EORTC 22845 randomised trial

Is there any role of chemotherapy in LGG?

3- Lancet NOV 2016 American Society of Clinical Oncology; 2013 (RCT)

Temozolomide chemotherapy versus radiotherapy in molecularly characterized (1p loss) low-grade glioma: A randomized phase III intergroup study by the EORTC/NCIC-CTG/TROG/MRC-CTU (EORTC 22033-26033

4- NEJM 2016 (RCT)

Radiation plus Procarbazine, CCNU,and Vincristine in Low-Grade Glioma

5- J Clin Oncol RTOG 9802 (RCT) SEP 2012

Randomized Trial of Radiation Therapy Plus Procarbazine, Lomustine, and Vincristine Chemotherapy for Supratentorial Adult Low-Grade Glioma: Initial Results of RTOG 9802

Neuro Oncol 2014 RTOG 9802 (RCT)

Practice changing mature results of RTOG study 9802: another positive PCV trial makes adjuvant chemotherapy part of standard of care in low-grade glioma

RT Dose- high vs Low?

Karim AB, Maat B, Hatlevoll R, Menten J, Rutten EH, Thomas DG, Mascarenhas F, Horiot JC, Parvinen LM, van Reijn M, Jager JJ. A randomized trial on dose-response in radiation therapy of low-grade cerebral glioma: European Organization for Research and Treatment of Cancer (EORTC) Study 22844. International Journal of Radiation Oncology* Biology* Physics. 1996 Oct 1;36(3):549-56.

· Shaw E, Arusell R, Scheithauer B, O’fallon J, O’neill B, Dinapoli R, Nelson D, Earle J, Jones C, Cascino T, Nichols D. Prospective randomized trial of low-versus high-dose radiation therapy in adults with supratentorial low-grade glioma: initial report of a North Central Cancer Treatment Group/Radiation Therapy Oncology Group/Eastern Cooperative Oncology Group study. Journal of Clinical Oncology. 2002 May 1;20(9):2267-76.